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樊洲龙博士，课题组长(PI)、长聘教轨副教授、博士生导师。国家海外优青、上海市海外高层次人才、小米青年学者。2011年本科毕业于中国药科大学；2017年博士毕业于中国科学院上海药物研究所，导师为张翱研究员；2018-2024年在美国斯克里普斯研究所(Scripps Research)从事博士后研究，导师为美国科学院院士Jin-Quan Yu教授；2024年2月加入英国正版365首页官网。主要从事药物化学和有机化学研究，开发了药物骨架位点选择性修饰，构建多样性类药化合物库和DNA编码化合物库的新方法和新技术，应用于抗糖尿病和抗肿瘤小分子候选药物研发。曾获得博士国家奖学金、中国科学院朱李月华博士生奖、中国科学院优秀博士论文等奖项。在国际高水平期刊上发表SCI论文40余篇，申请专利6项，总引用1800余次，H-index为23。以通讯或第一作者(含共同)在Nature (1篇)，Nat. Catal. (1篇)，J. Am. Chem. Soc. (4篇)，Angew. Chem. Int. Ed. (2篇)等国际期刊发表研究论文23篇。

本课题组招收申请考核制博士生、直博生和硕士生，欢迎热衷科学研究的有志青年申请。

课题组主要围绕药物化学和有机合成开展工作，具体包括以下内容：
1. 基于药物优势骨架的位点选择性修饰新技术和新策略开发
2. 基于新靶点的抗糖尿病、抗肿瘤和抗病毒小分子候选药物开发

已发表论文详见：
https://scholar.google.com/citations?hl=en&user=hlcgXHMAAAAJ&view_op=list_works&sortby=pubdate

代表性论文：
1.Lu, H.#; Li, Y.#; Ma, N.#; Chen, R.; Wang, Y.; Chen, M.; Zhang, W.; Wang, X.; Jin, H.; Ding, C.; Chen, S.*; Zhang, A.*; Fan, Z.* Stereoselective C1-Arylation of Native Sugars via Ligand-Promoted Nickel Catalysis. J. Am. Chem. Soc., 2026, DOI: 10.1021/jacs.6c06488.
2.Chen, C.-Y.; Fan, Z.; Strassfeld, D. A.; Chan, H. S. S.; Cohen Suarez, M.; Hoque, M. E.; Yu, J.-Q.* Conformation-Driven C3-C(sp3)–H Arylation of Saturated Azacycles Using Pd Catalyst. Nat. Catal., 2026, 9, 620.
3.Xu, H.-J.#; Fan, Z.#; Bin-Bin Nian, B.-B.; Gu, C.-H.; Shen, S.-J.; Zhang, W.; Hu, Y.*; Yu. J.-Q.* Achieving Mono-Selective Palladium(II)-Catalyzed C–H Activation with Protein Ligands. Nat. Catal., 2025, 8, 948.
4.Fan, Z.; Hoque, M. E.; Wu, K.; Palkowitz, M. D.; Velaparthi, U.; Gillman, K. W.; Qiao, J. X.; Yu, J.-Q. Diversity-Oriented C–H Activation Reactions of the Naphthalene Scaffold. J. Am. Chem. Soc. 2025, 147, 33850.
5.Yang, W.; Wang, S.; Ji, S.; Wang, J.; Lian, S.; Li, Z.; Jansen, R. A.; Wu, W.; Niu, K.; Sun, Z.; Jia, Q.; Zheng, J.; Zhu, H.; Deng, X.; Wang, L.; Fan, Z.; Shi, Y.; Lieftink, C.; Guan, M.; Beijersbergen, R. L.; Qin, W.; Gao, Q.; Bernards, R.; Jin, H. CRISPR Screens Identify the ATPase VCP as a Druggable Therapeutic Vulnerability in Cholangiocarcinoma. Proc. Natl. Acad. Sci. U.S.A., 2025, 122, e2519568122.
6.Fan, Z.; Cai, X.; Sheng, T.; Yu, J.-Q. Synthesis of bicyclo [3.2.0] heptane lactones via a ligand-enabled Pd-catalyzed C(sp3)–H activation cascade. Chem. Sci., 2025, 16, 9436.
7.Lu, H.; Fan, Z.; Zou, Y.; Zhang, A.* Diversified Fluoroalkylation of Alkenes Using Quaternary Fluoroalkyl Alcohols as the Fluoroalkylating Reagents. Adv. Sci., 2025, 12, 2408781.
8.Wu, K.; Lam, N.; Strassfeld, D. A.; Fan, Z.; Qiao, J. X.; Liu, T.; Stamos, D.; Yu, J.-Q.* Palladium (II)-Catalyzed C–H Activation with Bifunctional Ligands: From Curiosity to Industrialization. Angew. Chem. Int. Ed., 2024, e202400509.

Before SJTU:
1.Fan, Z.#; Chen, X.#; Tanaka, K.; Park, H. S.; Lam, N. Y. S.; Wong, J. J.; Houk, K. N.*; Yu, J.-Q.* Molecular Editing of Aza-arene C–H Bonds by Distance, Geometry and Chirality. Nature, 2022, 610, 87.
2.Fan, Z.#; Strassfeld, D. A.#; Park, H. S.; Wu, K.; Yu, J.-Q.* Formal γ−C–H Functionalization of Cyclobutyl Ketones: Synthesis of syn-1,3-Difunctionalized Cyclobutanes. Angew. Chem. Int. Ed., 2023, 62, e202303948.
3.Lam, N. Y. S.#; Fan, Z.#; Wu, K.#; Park, H. S.; Shim, S. Y.; Strassfeld, D. A.; Yu, J.-Q.* Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and Experimental Analyses. J. Am. Chem. Soc., 2022, 144, 2793.
4.Fan, Z.#, Bay, K. L.#; Chen, X.; Zhuang, Z.; Park, H. S.; Yeung, K.-S.; Houk, K. N.*; Yu, J.-Q.* Rational Development of Remote C–H Functionalization of Biphenyl: Experimental and Computational Studies. Angew. Chem. Int. Ed., 2020, 59, 4770. (hot paper)
5.Fan, Z.; Ni, J.; Zhang, A.* Meta-Selective C–H Nitration of Arenes through a Ru3(CO)12-Catalyzed Ortho-Metalation Strategy. J. Am. Chem. Soc., 2016, 138, 8470. (JACS spotlights; JACS cover; C&EN, 2016, 94, 9; Synfacts, 2016, 12, 1001)
6.Fan, Z.; Cai, X.; Sheng, T.; Yu, J.-Q. Synthesis of bicyclo [3.2.0] heptane lactones via a ligand-enabled Pd-catalyzed C(sp3)–H activation cascade. Chem. Sci., 2025, 16, 9436.
7.Fan, Z.#, Zhao, S.#; Liu, T.; Shen, P.-X.; Cui, Z.-N.; Zhuang, Z.; Shao, Q.; Chen, J. S.; Ratnayake, A. S.; Flanagan, M. E.; Kölmel, D. K.; Piotrowski, D. W.; Richardson, P.; Yu, J.-Q.* Merging C(sp3)–H activation with DNA-encoding. Chem. Sci., 2020, 11, 12282. (front cover; news on Chemistry World)
8.Fan, Z.; Shu, S.; Ni, J.; Yao, Q.; Zhang, A.* Ligand-Promoted Pd(II)-Catalyzed Functionalization of Unactivated C(sp3)–H Bond: Regio- and Stereoselective Synthesis of Arylated Rimantadine Derivatives. ACS Catal., 2016, 6, 769.